West Ham's Moroccan summer signing Nayef Aguerd is out after picking up an ankle injury in a pre-season friendly.
Manager David Moyes will also be without another new acquisition, Italian striker Gianluca Scamacca, who is not considered match fit.
Manchester City defender Aymeric Laporte is sidelined until September after undergoing knee surgery.
Utd were rubbish today. Even at 1-2, they didn't offer much going forward. Never controlled the game. And they never will with Fred and McTominey in midfield. And how Maguire is still captain is beyond me.